Cut the onion into bite-sized pieces and separate the layers.
In a large bowl, whisk together the flour, paprika, garlic powder, onion powder, salt, black pepper, and cayenne pepper.
In another bowl, pour the buttermilk.
Place the breadcrumbs in a third bowl.
Dip each onion piece into the buttermilk, then coat it in the flour mixture, back into the buttermilk, and finally roll it in the breadcrumbs until fully coated.
Heat about 2 inches of vegetable oil in a deep pot over medium heat until it reaches 350°F.
Carefully add the coated onion pieces in batches, frying for about 3-4 minutes or until golden brown and crispy.
Remove the fried onions with a slotted spoon and place them on a paper towel-lined plate to drain excess oil.
Serve warm with your favorite dipping sauce.