In a skillet over medium-high heat, add the ground beef. Break it apart with a spatula and cook until browned, about 5-7 minutes. Drain excess fat if necessary.
Stir in garlic powder, onion powder, smoked paprika, salt, and pepper. Cook for an additional 2-3 minutes until the spices are well incorporated.
In a large bowl, layer the mixed salad greens as the base. Top with the cooked ground beef, cherry tomatoes, cucumber, avocado, shredded cheddar cheese, and pickles.
Drizzle with burger sauce before serving. Toss gently to combine if desired.
Serve immediately or refrigerate for up to 2 hours before serving for a chilled option.