In a skillet over medium heat, cook the ground beef until browned, about 5-7 minutes. Drain excess fat.
Stir in onion powder, garlic powder, salt, black pepper, and Worcestershire sauce. Cook for an additional 2-3 minutes, mixing well.
Lay out the flour tortillas on a clean surface.
Divide the cooked beef mixture evenly among the tortillas, placing it in the center of each.
Top each with shredded lettuce, diced tomatoes, shredded cheddar cheese, and pickles.
Drizzle Thousand Island dressing over the toppings.
Fold in the sides of each tortilla and roll it up tightly from the bottom to the top.
Slice each wrap in half and serve immediately.